2012-03-29 Pathology Report

1. BRAIN, LEFT FRONTAL TUMOR, CRANIOTOMY/RESECTION:

  • GLIOBLASTOMA (WHO GRADE IV).

2. BRAIN, LEFT FRONTAL TUMOR, CRANIOTOMY/RESECTION:

  • GLIOBLASTOMA (WHO GRADE IV), PLEASE SEE COMMENT.

Comment

The glioma shows regions of high cellularity composed of small atypical hyperchromatic cells showing brisk mitotic activity, florid associated vascular proliferative changes and focal necrosis are present. There is evident organizing and old hemorrhage. The tumor shows infiltrative and solid regions of compact growth.  Immunostains (block 2A) show strong GFAP positivity, solid and infiltrative patterns on neurofilament, positive components on p53, and
negative IDH-1. Prominent reticulin is not seen in the tumor (reticulin stain).

Representative tissue will be provided for MGMT methylation analysis (2B, LabCorp), and those results will be reported separately when completed.

Specimen(s) Received
Left frontal tumor
Left frontal tumor

Intraoperative Consultation
FROZEN SECTION DIAGNOSIS:
HIGH GRADE/MALIGNANT GLIOMA. (JDD).

Gross Description

1. Left frontal tumor: Received fresh labeled “left frontal tumor” and consists of a 2 x 0.5 x 0.4 cm soft rubbery pinkish-red, partially hemorrhagic portion of tissue, which is bisected. Half submitted for frozen section and remaining for paraffin embedment.

2. Left frontal tumor: Received in formalin labeled with the patient’s name, medical record number and “left frontal tumor” is a 3.7 x 2.4 x 0.7 cm aggregate of pink-red soft tissue fragments. The specimen is sectioned and entirely submitted.

We requested that the samples be sent to MD Anderson for analysis, and they confirmed these findings.

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